Free PDF GPCR Signalling Complexes - Synthesis Assembly Trafficking and Specificity (Subcellular Biochemistry)
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Published on: 2012-11-17
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Original language: English
Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again Pharmacological chaperones may just be part of the answer to this question. Sample Files - BioTek Kevin J. Forsberg Sanket Patel Evan Witt Bin Wang Tyler Ellison and Gautam Dantas (2015). "Functional selections of soil metagenomes identify tolerance genes ... Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... Oxbridge essays scampi shrimp recipe nobu-zzvc Oxbridge essays scampi shrimp recipe nobu-zzvc Samedi 14 mar 2015 Adaptation of Rod Photoreceptors to Light and Dark Adaptation of Rod Photoreceptors to Light and Dark Magorzata Ranowska Cardiff Centre for Vision Science Cardiff University Maindy Road Cardiff CF24 4LU Wales ... Applications : BioTek Applications. The following resources are available to illustrate product specific capabilities and common applications for BioTek microplate instrumentation. Ontogeny Anatomy Metabolism and Physiology of the ... ABSTRACT. This chapter presents an analysis and a summarized synthesis of our present knowledge of the biology of the thyroid gland phylogeny ontogeny ...
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